Drosophila Developmental Genetics

Lipid phosphate phosphatases

Lipid phosphate phosphatases

We are interested in understanding the developmental roles of lipid phosphate phosphatases (LPPs), encoded by the genes wunen (wun) and wunen2 (wun2) in Drosophila. LPPs are a class of multi-pass transmembrane enzymes that potentially function both intracellularly and at the cell surface to regulate lipid phosphate levels. In vitro substrates include phosphatidic acid, lysophosphatidic acid, sphingosine 1-phosphate and ceramide 1-phosphate.

LPPstructure

LPPs (conserved and catalytic domains in yellow and red respectively) at the cell surface can dephosphorylate substrates such as sphingosine 1-phosphate leading to uptake of the lipid moiety.